BENZYL MANNAN

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Polymorphisms in Mannan-Binding Lectin

Benzyl Penicillin

The search for an orally administered and stable penicillin preparation with high therapeutic efficacy led to the recent discovery that the benzyl ester of penicillin, given orally, was at least equal in protective effect to the equivalent weight of sodium penicillin administered parenterally to mice that had received lethal doses of pneumococci and hemolytic streptococci by intraperitoneal inj...

Genetic control of yeast mannan structure. Isolation and characterization of mannan mutants.

The yeast Saccharomyces cerevisiae X2180, the strain most commonly used for genetic studies on yeasts, was treated with the mutagen ethyl methanesulfonate, and mutants defective in the synthesis of cell wall mannan were isolated. The initial selection of mutants was made on the basis of their failure to agglutinate with antiserum that was specific for the mannotetraose side chain of the mannan,...

Introduction to mannan-binding lectin.

Mannan-binding lectin (MBL) was first discovered as a plasma opsonin for baker's yeast and was independently characterized biochemically. It belongs to the small subfamily of collectins: C-type lectins possessing a collagen-like domain. MBL is synthesized by the liver and secreted into the bloodstream. It is believed to be an important component of innate immunity, acting as an ante-antibody an...